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    CVE-2024-50636

    PyMOL 2.5.0 contains a vulnerability in its "Run Script" function, which allows the execution of arbitrary Python code embedded within .PYM files. Attackers can craft a malicious .PYM file containing a Python reverse shell payload and exploit the function to achieve Remote Command Execution (RCE). This vulnerability arises because PyMOL treats .PYM files as Python scripts without properly validating or restricting the commands within the script, enabling attackers to run unauthorized commands in the context of the user running the application.

    Published:Nov 11, 2024
    Last Modified:Apr 15, 2026
    EPS:Nov 11, 2024
    EPSS Score:0.06957
    CVSS Score:9.8

    Affected Products

    Vendor
    Schrodinger
    Product
    Pymol

    Exploits

    No exploit reference

    Common Vulnerability Scoring System

    Attack Vector
    Network
    Adjacent
    Local
    Physical
    Privileges Required
    None
    Low
    High
    User Interaction
    None
    Required
    Scope
    Unchanged
    Changed
    Confidentiality
    None
    Low
    High
    Integrity
    None
    Low
    High
    Availability
    None
    Low
    High