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    CVE-2025-12921

    A vulnerability has been found in OpenClinica Community Edition up to 3.12.2/3.13. Affected by this issue is some unknown functionality of the file /ImportCRFData?action=confirm of the component CRF Data Import. Such manipulation of the argument xml_file leads to xml injection. It is possible to launch the attack remotely. The exploit has been disclosed to the public and may be used. The vendor was contacted early about this disclosure but did not respond in any way.

    Published:Nov 9, 2025
    Last Modified:Dec 2, 2025
    EPS:Nov 9, 2025
    EPSS Score:0.00034
    CVSS Score:4.3

    Affected Products

    Vendor
    Openclinica
    Product
    Openclinica

    Exploits

    https://github.com/mikecole-mg/security_findings/blob/main/openclinica/openclinica-xxe.mdhttps://github.com/mikecole-mg/security_findings/blob/main/openclinica/openclinica-xxe.md#pochttps://github.com/mikecole-mg/security_findings/blob/main/openclinica/openclinica-xxe.mdhttps://github.com/mikecole-mg/security_findings/blob/main/openclinica/openclinica-xxe.md#poc

    Common Attack Pattern Enumeration and Classification (CAPEC)

    CAPEC-10 Buffer Overflow via Environment Variables
    CAPEC-101 Server Side Include (SSI) Injection
    CAPEC-105 HTTP Request Splitting
    CAPEC-108 Command Line Execution through SQL Injection
    CAPEC-120 Double Encoding
    CAPEC-13 Subverting Environment Variable Values
    CAPEC-135 Format String Injection
    CAPEC-14 Client-side Injection-induced Buffer Overflow
    CAPEC-24 Filter Failure through Buffer Overflow
    CAPEC-250 XML Injection
    CAPEC-267 Leverage Alternate Encoding
    CAPEC-273 HTTP Response Smuggling
    CAPEC-28 Fuzzing
    CAPEC-3 Using Leading 'Ghost' Character Sequences to Bypass Input Filters
    CAPEC-34 HTTP Response Splitting
    CAPEC-42 MIME Conversion
    CAPEC-43 Exploiting Multiple Input Interpretation Layers
    CAPEC-45 Buffer Overflow via Symbolic Links
    CAPEC-46 Overflow Variables and Tags
    CAPEC-47 Buffer Overflow via Parameter Expansion
    CAPEC-51 Poison Web Service Registry
    CAPEC-52 Embedding NULL Bytes
    CAPEC-53 Postfix, Null Terminate, and Backslash
    CAPEC-6 Argument Injection
    CAPEC-64 Using Slashes and URL Encoding Combined to Bypass Validation Logic
    CAPEC-67 String Format Overflow in syslog()
    CAPEC-7 Blind SQL Injection
    CAPEC-71 Using Unicode Encoding to Bypass Validation Logic
    CAPEC-72 URL Encoding
    CAPEC-76 Manipulating Web Input to File System Calls
    CAPEC-78 Using Escaped Slashes in Alternate Encoding
    CAPEC-79 Using Slashes in Alternate Encoding
    CAPEC-8 Buffer Overflow in an API Call
    CAPEC-80 Using UTF-8 Encoding to Bypass Validation Logic
    CAPEC-83 XPath Injection
    CAPEC-84 XQuery Injection
    CAPEC-9 Buffer Overflow in Local Command-Line Utilities

    Common Vulnerability Scoring System

    Attack Vector
    Network
    Adjacent
    Local
    Physical
    Privileges Required
    None
    Low
    High
    User Interaction
    None
    Required
    Scope
    Unchanged
    Changed
    Confidentiality
    None
    Low
    High
    Integrity
    None
    Low
    High
    Availability
    None
    Low
    High