Palo Alto Networks Brings Continuous AI Defense and Prisma AIRS to the OpenAI Marketplace

Palo Alto Networks announces thatUnit 42® Continuous Frontier AI DefenseandPrisma AIRS™are now on the newly launchedOpenAI Marketplace,making them directly available to OpenAI’s enterprise customers. Threat actors are deploying artificial intelligence to find and exploit vulnerabilities at unprecedented speed, compressing breach cycles byalmost 97%—from weeks down to mere hours. Human-speed defense can no longer keep pace with adversaries executing automated, continuous attacks.

For enterprise organizations holding OpenAI spend commitments, this milestone offers a compelling 2-for-1 financial and strategic advantage. Security teams can now deploy machine-speed, proactive defense while retiring their pre-committed OpenAI spend.Palo Alto Networks offers two flagship solutions available for procurement through the OpenAI Marketplace.

Unit 42 Continuous Frontier AI Defenseis an expert-led, agentic offensive security service engineered to identify, validate, and remediate enterprise exposures as an organization’s environment changes.

This always-on, agentic service combines our offensive security experts with our proprietary multi-model harness, which uses defender-grade frontier models to discover vulnerabilities, validate real-world exploitability, and accelerate remediation across applications, identities, cloud infrastructure, and network assets as an organization’s environment changes.At the core of this capability is our proprietary multi-model software harness that dynamically routes security tasks to the optimal AI model, maximizing efficacy and coverage while managing the cost of frontier AI at scale.

The harness integrates defender-grade models, includingOpenAI’s GPT-5.6-Cyber, and other commercial models alongside open-weight models and Unit 42 threat intelligence. By executing non-destructive adversary simulations across first- and third-party environments, the system proves actual exploitability and delivers prioritized remediation guidance including actionable fixes, code-level changes, and virtual patches. Organizations can pair this with Frontier Virtual Patching to block exploits long before official patches exist or CVEs are publicly disclosed.

The real-world impact of this proactive methodology was validated over six months of in-house testing and across more than 75 customer engagements backed by a $17 million R&D investment. During internal deployment within Palo Alto Networks, the service uncovered over two years’ worth of exposures in just three weeks. In customer assessments, the underlying analysis identified exposures in 100% of assessed organizations, with 37% rated high or critical severity. Crucially, over two-thirds of exposures found in third-party applications had no known CVE, proving the urgent necessity of continuous, AI-driven discovery.

Unit 42 Continuous Frontier AI Defense is available worldwide today on an annual subscription basis. Register for our upcoming Virtual Threat Briefing to see how we apply Frontier AI, our proprietary multi-model harness, and offensive security expertise to protect Palo Alto Networks and our customers.

To learn more aboutUnit 42 Continuous Frontier AI Defense, register for the upcoming Virtual Threat Briefinghere.

As OpenAI customers rapidly scale their use of powerful AI models, AI coding assistants, and autonomous agents, the enterprise attack surface is expanding faster than traditional security teams can manage. The transition to autonomous AI breaks traditional security boundaries, creating shadow AI blind spots, supply chain risks in open-source base models, unsafe actions from malicious inputs, and uncontrolled AI agents executing tasks with excessive permissions.

Prisma AIRS: Secure Every AI Ambition

Prisma AIRS is the Palo Alto Networks unified AI security platform, enabling enterprises to accelerate AI adoption while maintaining control over sensitive data, agent identities, autonomous actions and AI costs. Recognized byGartner as a Market Shaper in the September 2026 Emerging Market Quadrant for AI Application Security – Established Vendors, Palo Alto Networks brings together discovery, continuous risk assessment, real-time protection and centralized governance to secure AI applications and agents across enterprise environments.

Together, these capabilities help OpenAI enterprise customers secure AI-powered workflows, maintain accountability for autonomous actions and scale AI adoption with consistent security and governance.Book a demoto see our AI Security solution in action.

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