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    CVE-2026-48705

    MONAI (Medical Open Network for AI) is an AI toolkit for health care imaging. Prior to 1.6.1, PydicomReader._get_affine() trusts non-finite values in the DICOM PixelSpacing, ImagePositionPatient, and ImageOrientationPatient fields and composes them into an affine matrix without validation. An unauthenticated attacker who can upload a crafted DICOM to a default MONAILabel deployment can propagate NaN or infinity values through LoadImaged, Spacingd, model inference, and output writing, causing inference failures, persistent datastore poisoning, or geometrically corrupted results. This issue is fixed in version 1.6.1.

    Published:Nov 5, 2026
    Last Modified:Nov 5, 2026
    EPS:Nov 5, 2026
    EPSS Score:
    CVSS Score:9.3

    Affected Products

    Vendor
    Project-monai
    Product
    Monai

    Exploits

    No exploit reference

    Common Attack Pattern Enumeration and Classification (CAPEC)

    CAPEC-10 Buffer Overflow via Environment Variables
    CAPEC-101 Server Side Include (SSI) Injection
    CAPEC-104 Cross Zone Scripting
    CAPEC-108 Command Line Execution through SQL Injection
    CAPEC-109 Object Relational Mapping Injection
    CAPEC-110 SQL Injection through SOAP Parameter Tampering
    CAPEC-120 Double Encoding
    CAPEC-128 Integer Attacks
    CAPEC-129 Pointer Manipulation
    CAPEC-13 Subverting Environment Variable Values
    CAPEC-135 Format String Injection
    CAPEC-136 LDAP Injection
    CAPEC-14 Client-side Injection-induced Buffer Overflow
    CAPEC-153 Input Data Manipulation
    CAPEC-182 Flash Injection
    CAPEC-209 XSS Using MIME Type Mismatch
    CAPEC-22 Exploiting Trust in Client
    CAPEC-23 File Content Injection
    CAPEC-230 Serialized Data with Nested Payloads
    CAPEC-231 Oversized Serialized Data Payloads
    CAPEC-24 Filter Failure through Buffer Overflow
    CAPEC-250 XML Injection
    CAPEC-261 Fuzzing for garnering other adjacent user/sensitive data
    CAPEC-267 Leverage Alternate Encoding
    CAPEC-28 Fuzzing
    CAPEC-3 Using Leading 'Ghost' Character Sequences to Bypass Input Filters
    CAPEC-31 Accessing/Intercepting/Modifying HTTP Cookies
    CAPEC-42 MIME Conversion
    CAPEC-43 Exploiting Multiple Input Interpretation Layers
    CAPEC-45 Buffer Overflow via Symbolic Links
    CAPEC-46 Overflow Variables and Tags
    CAPEC-47 Buffer Overflow via Parameter Expansion
    CAPEC-473 Signature Spoof
    CAPEC-52 Embedding NULL Bytes
    CAPEC-53 Postfix, Null Terminate, and Backslash
    CAPEC-588 DOM-Based XSS
    CAPEC-63 Cross-Site Scripting (XSS)
    CAPEC-64 Using Slashes and URL Encoding Combined to Bypass Validation Logic
    CAPEC-664 Server Side Request Forgery
    CAPEC-67 String Format Overflow in syslog()
    CAPEC-7 Blind SQL Injection
    CAPEC-71 Using Unicode Encoding to Bypass Validation Logic
    CAPEC-72 URL Encoding
    CAPEC-73 User-Controlled Filename
    CAPEC-78 Using Escaped Slashes in Alternate Encoding
    CAPEC-79 Using Slashes in Alternate Encoding
    CAPEC-8 Buffer Overflow in an API Call
    CAPEC-80 Using UTF-8 Encoding to Bypass Validation Logic
    CAPEC-81 Web Server Logs Tampering
    CAPEC-83 XPath Injection
    CAPEC-85 AJAX Footprinting
    CAPEC-88 OS Command Injection
    CAPEC-9 Buffer Overflow in Local Command-Line Utilities

    Related CVEs

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    CVE-2026-109361 (CVSS 7) — MONAI 1.2.0 before 1.6.1 contains an insecure deserialization vulnerability in nnUNetV2Runner that unpickles t…
    CVE-2026-109360 (CVSS 7.7) — MONAI 0.4.0 before 1.6.1 contains a remote code execution vulnerability that allows on-path attackers to execu…
    CVE-2026-100846 (CVSS 8.8) — MONAI before 1.5.2 contains a deserialization of untrusted data vulnerability in the algo_from_pickle function…
    CVE-2026-100845 (CVSS 8.5) — MONAI before 1.6.0 contains an unsafe deserialization vulnerability in the NumpyReader class that unconditiona…
    CVE-2026-100844 (CVSS 8.6) — MONAI before 1.6.0 is vulnerable to OS command injection in the nnUNetV2Runner component (monai.apps.nnunet.nn…
    CVE-2026-100843 (CVSS 8.5) — MONAI versions before 1.6.0 contain a remote code execution vulnerability in the algo_from_pickle() function d…
    CVE-2026-100842 (CVSS 7.3) — MONAI through 1.6.0 contains an eval injection vulnerability in _get_fake_spatial_shape() in monai/bundle/scri…

    Common Vulnerability Scoring System

    Attack Vector
    Network
    Adjacent
    Local
    Physical
    Privileges Required
    None
    Low
    High
    User Interaction
    None
    Required
    Scope
    Unchanged
    Changed
    Confidentiality
    None
    Low
    High
    Integrity
    None
    Low
    High
    Availability
    None
    Low
    High